Chronic myeloid leukaemia occurring in a patient with hairy cell leukaemia.

نویسندگان

  • F A Wandroo
  • D Bareford
  • F el-Jehani
چکیده

Occurrences of second malignancies in hairy cell leukaemia are well recognised. Most of these malignancies are either solid tumours or lymphoproliferative disorders. The association of myeloproliferative disorders with hairy cell leukaemia (HCL) is very rare. This report describes a case of a patient with HCL who after remaining in remission developed Philadelphia chromosome positive chronic myeloid leukaemia (CML), which rapidly transformed to acute lymphoblastic leukaemia with further cytogenetic abnormalities.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Detection of abl/bcr Fusion Gene in Patients Affected by Chronic Myeloid Leukaemia by Dual-Colour Interphase Fluorescence in situ Hybridisation

Conventional cytogenetic is the standard technique for detection of Philadelphia (Ph) chromosome in chronic myeloid leukemia (CML). Evaluation of abelson murine leukemia/breakpoint cluster region (abl/bcr) fusion using dual-colour fluorescence in situ hybridization (D-FISH) is an alternative approach allowing rapid and reliable detection of the disease. We employed the technique of interphase D...

متن کامل

Expression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow

Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute m...

متن کامل

p53 EXPRESSION IN HAEMATOLOGICAL MALIGNANCIES: RESPONSE TO ALKYLATING AGENT IN THE COMET ASSAY

Aims. The P53 gene is a tumour suppressor, often inactivated by deletion and/or point mutation in malignancies. The incidence of p53 mutation in haematological malignancies varies with malignancy type and cell lineage affected. It is associated with disease progression, poor prognosis and resistance to chemotherapy. The wild-type p53 protein has a short half-life and cannot be detected by immun...

متن کامل

Cyclic oscillations of leucocyte counts in chronic myeloid leukaemia.

A patient with chronic myeloid leukaemia, having two unusual features, is described. He had absence of splenomegaly and marked periodic fluctuations of leucocyte counts, occurring spontaneously, in the initial phase of the disease. The latter finding suggests that, at least in some patients with chronic myeloid leukaemia, negative feed back control mechanism(s), possibly exerted by colony stimu...

متن کامل

Kaposi's sarcoma associated with hairy cell leukaemia.

Hairy cell leukaemia is a rare condition and the patient reported here is only the third such case out of 527 patients with all types of leukaemia seen at our hospital over the last 4 years. A second malignancy in a patient with hairy cell leukaemia has been documented in detail only once before (Adler, Shetty and Golomb, 1979). The association of Kaposi's sarcoma, a common tumour in parts of s...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of clinical pathology

دوره 53 12  شماره 

صفحات  -

تاریخ انتشار 2000